Comparative Study between Clomiphene Citrate plus Phytoestrogens and Clomiphene Citrate plus N–acetyl–Cysteine in Clomiphene Citrate Resistant Polycystic Ovary Syndrome

Mohamed Lofty; Walid A.Abdelsalam; Shymma Abdelazim

Volume : IV, Issue : I, January - 2015

Comparative Study between Clomiphene Citrate plus Phytoestrogens and Clomiphene Citrate plus N–acetyl–Cysteine in Clomiphene Citrate Resistant Polycystic Ovary Syndrome

Mohamed Lofty, Walid A. Abdelsalam, Shymma Abdelazim

Abstract :

PCOS is the commonest endocrinopathy in reproductive age. Adjuvant agents with clomiphene citrate in C.C.resistant PCOS inducing good ovulatory rates and fewer side-effects. Patients and methods: Patients divided into two groups: group (A) (n=40) received C.C. 100mg/day for 5 days+Klimadynon,20 mg for 10 days; and group (B) (n=40) received C.C. 100 mg daily for 5 days+NAC 1.2 gm for 5 days. Monitoring of the patients on the 3rd day of the menstrual cycle include baseline TVS and hormonal changes. On the 12th day of the cycle, TVS was done to evaluate the follicular diameter and endometrial thickness. Serum progesterone was measured on cycle day 21 and b-hCG level was measured on the 14th day after hCG injection if menses not occurred. Results: Significant hormonal changes and endometrial thickness was greater in the Klimadynon group. Insulin sensitivity was increased in NAC group in all three treatment cycles.