COMPARATIVE STUDY BETWEEN DEXMEDETOMIDINE VERSUS PROPOFOLKETAMINE VERSUS PROPOFOLFENTANYL WHEN USED FOR SEDATION DURING GASTROINTESTINAL ENDOSCOPIES

P SATEESH KUMAR; DR A PADMAJA; DR A SATYANNARAYANA; DR KHASIM

Volume : V, Issue : VII, July - 2016

COMPARATIVE STUDY BETWEEN DEXMEDETOMIDINE VERSUS PROPOFOLKETAMINE VERSUS PROPOFOLFENTANYL WHEN USED FOR SEDATION DURING GASTROINTESTINAL ENDOSCOPIES

P Sateesh Kumar, Dr A Padmaja, Dr A Satyannarayana, Dr Khasim

Abstract :

OBJECTIVE ; The aim of this study is to compare Dexmedetomidine,propofol– ketamine and propofol– fentanyl for the sedation of patients undergoing upper gastrointestinal endoscopic procedures in terms of induction and recovery profiles, sedation and adverse effects ,patient and endoscopist satisfaction. MATERIALS AND METHODS; After approval from hospital ethics committee a randomized comparative study was conducted in 9patients who were undergoing upper gastrointerstinal endoscopies in the Department of Gasteroenterology. Patients were randomized into 3 groups of 30 each by computer generated random numbers. Group 1(n=30), patients received loading dose of inj.Dexmedetomidine 1.5 �g/kgi.v infused over 10 min followed by maintainance infusion at a rate of 0.5�g/kg/hr.Group 2(n=30),patients received inj ketamine 0.5mg/kg i.v and inj.Propofol1–2 mg/kgi.v followed by infusion of inj.propofol50�g/ kg/min i.v as maintainance.Group 3(n=30),patients received inj. fentanyl 1�g/kg i.v and inj.Propofol1–2 mg/kgi.vfollowed by infusion of inj.propofol 50�g/kg/min i.v as maintainance. All procedures were performed after achieving a sedation level of 4–5 Ramsay sedation score RESULTS ; .Results were analysed by Analysis of variance [ANOVA] tests.P value <0.05 was considered to be significant. There was a statistically significant difference between groups with respect to the induction time and recovery time. Induction time was shorter in ketamine propofol group than propofol fentanyl group and dexmedetomidine group.However recovery was faster in propofol fentanyl group when compared to other groups. CONCLUSION :Patients in Propofol Fentanyl group have early induction and faster recovery profiles with lower incidence of side effects compared to Dexmedetomidine and Ketamine Propofol groups. There by Propofol Fentanyl combination can be used as a safe sedative regimen in upper Gastrointestinal endoscopies.