Volume : V, Issue : VIII, August - 2016

Comparative Study of Fluoxetine and Escitalopram : The Impact of SSRI’s on Sleep and Anxiety

Dr Shubham Verma

Abstract :

 Fluoxetine (20 mg) was compared to escitalopram (10 mg) in a prospective, double blind, randomised clinical trial involving 125 patients with major depression treated for an initial phase of 6 weeks and then followed up for a further 6 months. There was no difference in the efficacy of the two drugs based on the results of established rating scales (MADRS, HAM–D, BPRS). The impact of both drugs on sleep measured using the Leeds Sleep Evaluation Questionnaire showed no significant differences between treatments, however drowsiness and disturbed sleep were reported more frequently as side effects with escitalopram. Symptoms of anxiety responded equally well to both treatments. Our study has confirmed that fluoxetine is as effective as escitalopram in the acute treatment of major depression and has shown that fluoxetine has a better tolerability profile without loss of the beneficial effect of normalising sleep. In addition fluoxetine has been shown to be as effective as escitalopram in relieving the symptoms of anxiety associated with depression

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr Shubham Verma Comparative Study of Fluoxetine and Escitalopram : The Impact of SSRI¥s on Sleep and Anxiety International Journal of Scientific Research,Volume : 5 | Issue : 8 |August 2016

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