Comparative study of hypertensive disorder in pregnant women with sickle cell disease and trait

DR. MAYANK R. PATEL; DR. NILAM PRAJAPATI; DR. JAGRUTI ANAVADIYA

Volume : IV, Issue : I, January - 2015

Comparative study of hypertensive disorder in pregnant women with sickle cell disease and trait

Dr. Mayank R. Patel, Dr. Nilam Prajapati, Dr. Jagruti Anavadiya

Abstract :

• Objectives: To compare the incidence of hypertensive disorder in pregnant women with sickle cell disease and trait. Methods: This was a prospective observational study in the Obstetrics and gynecology dept, New Civil Hospital, Surat. Pregnant women with Surname:[Thodia, Dubla ,Kokna, Gamit, Chaudhary, Halpati, Vasava, Patel, Nayka, Varni, Kokani, Kathodi, Kolcha, Kotwadia] and all women with anemia attending the Antenatal OPD or admitted to obstetrics ward or labour room were screened for sickle cell anemia. Blood sample of casesthat had positive sickling test were subjected to Hb electrophoresisto differentiate SS(SCD) from AS(SCT). 29 SCD and 65 SCT identified and enrolled as subjects in my study. Both group were matched for age, gravidity and other demographic factors. The antenatal management of these subjects was done according to their associated complications. Routine intranatal monitoring and management was done. The same care was continued in post natal period and these subjects were discharged in 5th postnatal day in absence of any fetomaternal complication. The detail of anemia, PIH, PET, chronic hypertension and Eclampsia, sickle cell crisis were noted. Results: Out of 94, sickle cell disease (SS) was found in 29 cases (30.85%) and sickle cell trait (AS) in 65cases (69.15%). Incidence of hypertension (PIH / chronic hypertension) in SSD group was 44% and in SST group was 26%. Incidence of Eclampsia in both group respectively was 27.58%(SSD) and 4.61%(SST). • Conclusions: Subjects with SSD were more likely to have Eclampsia and Hypertensive disorder as compared to those with SST.