Comparative Study of Intraperitoneal Instillation of 0.5% Bupivacaine with Adrenaline and Placebo for Postoperative Analgesia in Laparoscopic Cholecystectomy

Dr Rajanikant S M; Dr Naveen kumar C P; Dr Akkamahadevi P

Volume : III, Issue : VII, July - 2014

Comparative Study of Intraperitoneal Instillation of 0.5% Bupivacaine with Adrenaline and Placebo for Postoperative Analgesia in Laparoscopic Cholecystectomy

Dr Rajanikant S M, Dr Naveen Kumar C P, Dr Akkamahadevi P

Abstract :

Background : This study was designed to know the analgesic effects of bupivacaine administered intraperitoneally in patients undergoing laparoscopic cholecystectomy. Methods: prospective randomized clinical study was carried out on 100 patients belonging to ASA grade I&II, age group between 18-60yrs posted for elective laparoscopic cholecystectomy. Group A(study group) received 20 ml 0.5% bupivacaine with adrenaline intraperitoneally at gall bladder bed and under right hemidiaphragm both before and at the end of surgery through laparoscope port in trendelenburgh position. Group B(placebo group) received 20 ml normal saline intraperitoneally at the same location. Vital parameters, duration of effective analgesia were recorded and compared. Statistical analysis: Repeated measure ANOVA, Student �t� test and paired �t� test was used. Results: Study group provided a substantial reduction of pain intensity during the first 4 hours postoperatively and this was found to be statistically significant. Total rescue analgesic doses required in study group was less compared to placebo group. Conclusions: Bupivacaine is effective at preventing pain at wake-up and over the first 4-8h after laparoscopic cholecystectomy when intraperitoneally instilled at the beginning and end of laparoscopy