comparative study of intrathecal 0.5% hyperbaric bupivacaine alone with intrathecal low dose clonidine – 0.5% hyperbaric bupivacaine for hemodynamic response and post operative analgesia in orthopaedic lower limb surgeries

Dr.Sourabh Jain; Dr. Shankar Agrawal; Dr.Arti Jain

Volume : VII, Issue : I, January - 2018

comparative study of intrathecal 0.5% hyperbaric bupivacaine alone with intrathecal low dose clonidine – 0.5% hyperbaric bupivacaine for hemodynamic response and post operative analgesia in orthopaedic lower limb surgeries

Dr. Sourabh Jain, Dr. Shankar Agrawal, Dr. Arti Jain

Abstract :

Use of subarachnoid block (intrathecal) has become an established and reliable method of providing anesthesia for orthopedic lower limb surgery.

Aim: To compare intrathecal low dose clonidine – hyperbaric bupivacaine 0.5% combination with hyperbaric bupivacaine 0.5% in respect to hemodynamic response, analgesia duration and side effects in orthopedic lower limb surgeries.

Material and Methods: 90 patients enrolled in this study were randomly divided in 3 group of 30 each. Group I – received only 3ml 0.5% hyperbaric bupivacaine (15 mg) intrathecally while Group II & III– received 25�g and 50 �g Clonidine as adjuvant to 3 ml 0.5% hyperbaric bupivacaine respectively.

Results: The duration of anaesthesia i.e: regression of sensory level below L1, duration of analgesia and sedation score was maximum (clinically significant) in group III followed by group II then group I. The incidence of side effects like adycardia , hypotention , sedation & nausea /vomiting were more in Group III followed by group II then group I.

Conclusion: clonidine as an adjuvant to bupivacaine significantly increase the duration of anesthesia and post – operative analgesia. In view of sedative effect of 50 �g clonidine it should be used judiciously in ASA class>II patient.