IJSR - International Journal of Scientific Research

Sourabh Gupta; Satya Prakash Sharma

Volume : VI, Issue : IV, April - 2017

COMPARATIVE STUDY OF PHENYLEPHRINE, EPHEDRINE AND MEPHENTERMINE FOR TREATMENT OF HYPOTENSION DURING SPINAL ANESTHESIA FOR CAESAREAN SECTION

Sourabh Gupta, Satya Prakash Sharma

Abstract :

Background: Hypotension is one of the commonest problems following Spinal anesthesia which may require vasopressors to maintain normal blood pressure. This study compares the efficacy of intravenous bolus Phenylephrine, Ephedrine and Mephentermine for maintenance of blood pressure during Spinal anesthesia for Caesarean section.

Materials & Methods: The study population consisted of 75 patients undergoing elective caesarean section who developed hypotension following subarachnoid block. They were randomly allocated into 3 groups of 25 each to receive Group P–Phenylephrine 100 microgram, Group E– Ephedrine 6 mg, and Group M–Mephentermine 6 mg in 1 ml as bolus intravenously.

Results: It was found that rise of Systolic blood pressure for first 6 minutes after administration of study drugs was significantly higher in group P as compared to group E and group M(p<0.05). Similarly elevation of Diastolic blood pressure in group P was significantly higher as compared to other two groups for first 2 minutes. No significant differences were observed between changes in systolic and diastolic blood pressure of Ephedrine and Mephentermine group at any time. There was significant reduction in heart rate in Phenylephrine group but there was tachycardia following administration of Ephedrine and Mephentermine. Neonatal APGAR score were similar in all three groups.

Conclusion: All study drugs maintained Blood pressure within 20% of baseline values on intravenous administration however rise in BP within first 6 min after bolus dose was significantly higher in phenylephrine group in comparison to ephedrine and mephentermine group. Correction of hypotension was better sustained in phenylephrine group. Moreover, Phenylephrine group causes significantly lower heart rate. There was no undue effect on the fetus in any group as assessed by neonatal APGAR scores.