Volume : IV, Issue : IX, September - 2015

Comparative study of tablet Gabapentin 600 mg and tablet Gabapentin 1000 mg to attenuate the pressor response to laryngoscopy and tracheal intubation

Dr. Prof. Col V. R. R Chari, Dr Arnab Paul, Dr Monika Gulati, Drvinit Garg

Abstract :

<p>Background and objectives: Aim of this study was to compare the efficacy and safety of different doses of tab. gabapentin 600 mg, 1000 mg and oral placebo (control) to attenuate the pressor response to laryngoscopy and tracheal intubation and to compare the side effects with the use of it’s different dosages. Method: 90 patients, age 18–60 yrs of either sex belonging to ASA I or ASA II posted for elective surgery under general anaesthesia were selected and divided into three equal groups of 30 each. Group I (Control group) received oral placebo. Group II and Group III (Study groups) received 600 mg and 1000 mg of tab. gabapentin respectively 90 mins prior to surgery with a sip of water.Vital parameters such as PR,, NIBP, RR, EtCO2, SpO2 and side effects were noted at the interval of 1, 3, 5, 10 and 15 mins after laryngoscopy and tracheal intubation.. Result: Oral gabapentin 1000 mg attenuated the increase in SBP, DBP and MAP associated with laryngoscopy and intubation better than 600 mg but caused more side effects like drowsiness and sedation. The increase in heart rate response was not completely eliminated. Conclusion: Oral gabapentin 1000 mg is a better drug as compared to 600 mg to attenuate the pressor responses to laryngoscopy and tracheal intubation but tachycardiac response is not completely attenuated and it causes more drowsiness and sedation. Thus avoid any other sedation drug peri–operatively to prevent excessive drowsiness and sedation, when Gabapentin 1000 mg is used in the pre–medication.</p>

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr. Prof. (Col) V.R.R Chari, Dr Arnab Paul, Dr Monika Gulati, DrVinit Garg Comparative study of tablet Gabapentin 600 mg and tablet Gabapentin 1000 mg to attenuate the pressor response to laryngoscopy and tracheal intubation International Journal of Scientific Research, Vol : 4, Issue : 9 September 2015


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