Comparision of Different Doses Of Intravenously Administered Dexmedetomidine With Fentanyl On Haemodynamic Response To Intubation In Patients Undergoing Surgery Under General Anesthesia

Mukesh kumar; Ritesh kumar sinha

Volume : VI, Issue : V, May - 2017

Comparision of Different Doses Of Intravenously Administered Dexmedetomidine With Fentanyl On Haemodynamic Response To Intubation In Patients Undergoing Surgery Under General Anesthesia

Mukesh Kumar, Ritesh Kumar Sinha

Abstract :

Background : During general anesthesia , direct laryngoscopy and intubation results in a profound sympathoadrenal response which leads to tachycardia , hypertension and in predisposed individuals may lead to myocardial ischemia and arrhythmias. Various drugs such as opioids, lignocaine, propofol, beta blockers, alpha agonists have been used to minimize these adverse responses. Methods: 90 patients ASA1, ASA2 scheduled to undergo elective and emergency surgery under general anaesthesia were enrolled in double blind prospective randomized controlled trial. They were randomly allocated to one of the following groups. Group A received 2 micro gram/kg fentanyl intravenously10 minutes before induction. Group B received 2 micro gram/kg fentanyl and 0.5 microgram/kg dexmedetomidine intravenously 10 mins prior to induction. Group C received 2 mico gram/kg fentanyl and 1 microgram/kg dexmedetomidine i.v. 10 minutes prior to induction. Results: Both study groups(B & C) were comparable with respect to there heart rate at base line, 1 minute,2.5 minutes, 5 and 10 minutes after administration of the study drug. Group C(Dexmedetomidine 1μg) demonstrated a greater suppression of chronotropic response to intubation as compared together two groups. Both the groups (B & C) were comparable to their SBP at base line 5 and 10minutes Group C demonstrated a better suppression of the pressor response to intubation compared to other two groups.