Comparision of eradication rates of H.pylori between standard triple &dual drug regimen therapy

Dr.L.R.S.Girinadh; Dr.R.L.Praveen; Dr.M.Indrakeela Girish

Volume : VII, Issue : IX, September - 2018

Comparision of eradication rates of H.pylori between standard triple &dual drug regimen therapy

Dr. L. R. S. Girinadh, Dr. R. L. Praveen, Dr. M. Indrakeela Girish

Abstract :

BACKGROUND &AIMS: Helicobacter pylori is the most common chronic bacterial infection in the world with prevalence varying worldwide . To compare the eradication rates of H.pylori between treatment with 2weeks Clarithromycin based triple drug regimen & 6weeks dual drug regimen containing Amoxicillin &Omeprazole in patients with gastric or duodenal ulcer disease.

PATIENTS &METHODS: Prospective randomized controlled study.Totalsample size 197 .One arm receives triple drug regimen for 2 weeks. Second arm receives dual drug regimen for 6weeks.

RESULTS:Total 197 patients were included in the study of which 98 patients received triple drug regimen & 99 patients received dual drug regimen .H.pylori eradication rate between the triple drug regimen & dual drug regimen is statistically significant with p value 0.0142.

CONCLUSION:H.pylori eradication rate with dual drug regimen for 6 weeks is inferior to Clarithromycin based triple drug regimen for two weeks.