Comparison between cervical cytology (Papanicolaou smear) interpretation and HPV HR Cervista (third generation) in NILM cases: a tertiary care level laboratory experience from North India.

Ashish Gupta; Sonam Singh

Volume : VII, Issue : I, January - 2018

Comparison between cervical cytology (Papanicolaou smear) interpretation and HPV HR Cervista (third generation) in NILM cases: a tertiary care level laboratory experience from North India.

Ashish Gupta, Sonam Singh

Abstract :

According to (world health organization) WHO, cervical cancer is among the top 5 commonly diagnosed cancer in women and is the leading cause of mortality among females and is responsible for 2,70000 deaths annually.

Most consequential factor behind the high incidence and mortality rate in underdeveloped countries in comparison to developed is the absence of more sensitive diagnostic tool. Though introduction of Papanicolaou (pap) cervical smear test has helped preventing the disease but in our study where we have compared Pap screening with Cervista HPV invader screening and it was seen that pap cerivcal smear results are not always definitive and needs further corroboration with other sensitive molecular techniques as hyid capture technique, real time or conventional PCR for HPV detection or with HPV cervista technique based on DNA invader technology to catch the HPV infection which may be reported as false negative by standard pap cervical smear test which is based on morphological interpretation and has element of both inter and intra observer biasing.