Comparison of accelerated Radiation and Chemo - radiation in locally advanced carcinoma cervix: A prospective randomized, controlled study.

R. Srinath Bharadwaj; D. Aruna; M. Vijaya Kumar

Volume : VII, Issue : IV, April - 2018

Comparison of accelerated Radiation and Chemo - radiation in locally advanced carcinoma cervix: A prospective randomized, controlled study.

R. Srinath Bharadwaj, D. Aruna, M. Vijaya Kumar

Abstract :

Standard of care in locally advanced carcinoma cervix is Cisplatin based chemo – radiotherapy (CRT). Effectiveness of this modality in locally advanced cervical cancer patientswas unclear. In this randomized,prospective, controlled study, 60 patientswere randomized to either accelerated radiotherapy(ART) aloneor CRT followed by high dose rate intracavitary achytherapy (HDR – ICBT). The tumour response, Overall treatment time (OTT) and toxicities were recorded 6 weeks after HDR – ICBT. Complete response (CR) was observed in84.61% patients in ART and 86.2% of patients in CRT groups. Median OTT in ART group was 55.5 days and in the CRT group was 64 days. Overall toxicities were higher in the CRT group. ART decreased the overall treatment time compared to CRT, which has a proven benefit of improving survival.Both the modalities were equally effective in reducing the tumour size.