Comparison of Bispectral Index Values Produced by Isoflurane & Sevoflurane at Equal End-Tidal MAC in Trauma Surgeries under General Anaesthesia.

Dr Tarun Lall; Dr Rekha Verma

Volume : VIII, Issue : III, March - 2019

Comparison of Bispectral Index Values Produced by Isoflurane & Sevoflurane at Equal End-Tidal MAC in Trauma Surgeries under General Anaesthesia.

Dr Tarun Lall, Dr Rekha Verma

Abstract :

Back ground and aims: Awareness can be defined as the subjective experience of external or internal stimuli and one�s own existence in space and time at any given movement. A comparison of BIS values produced by sevoflurane, isoflurane at equal MAC and assessing which is better hypnotic agent. Method: – The study universe was randomly divided into 2 groups with 63 subjects of ASA I & II of age group 20 to 60 years of either sex. Group I (n=63) – Isoflurane (0.5,1, 1.5 MAC). Group S (n=63) – Sevoflurane (0.5,1, 1.5 MAC). Five minutes prior to induction both the groups were administered inj fentanyl 2�g/kg(i.v), induced by inj.propofol 2 mg/kg and inj. Rocuronium 1mg/kg10 min after the incision, the end–tidal concentration of the inhaled anaesthetic agent was adjusted to 0.5 MAC and kept constant for 10 min Then the inspired concentration of the inhaled anaesthetic agent was increase to 1.0 and 1.5 MAC collecting the data each time at the end of 10 min. The concentration were then decreased in the same graded manner from 1.5MAC to 1 and finally to 0.5 MAC, recording the various parameters each time. After each increment or decrement of the inhaled anaesthetic agent, the concentrations were kept constant for 10 min. BIS and hemodynamic were recorded after 10 min at each end tidal MAC conc. Chi–square test & Unpaired t–test was used to find out significant of proportion and the difference in means respectively. Result :– BIS value significant lower with sevoflurane as compared to isoflurane at equi–MAC. (P < 0.05) Conclusion: – The equi–MAC sevoflurane produces lower BIS values, so better Hypnotic agent as compared to isoflurane