Volume : VIII, Issue : VIII, August - 2019

COMPARISON OF ETOMIDATE AND PROPOFOL AS INDUCTION AGENT IN G.A.

Kanhaiya Lal Kishnani, Shailesh Mishra, Sanjay. P. Dave

Abstract :

Introduction:Presently Etomidate and Propofol are widely used as induction agents. Propofol has hemodynamic instability. The decrease in blood pressure, cardiac output and systemic vascular responses are not synchronized with patient compensatory responses. These are intensified in higher doses and more intense in hypovolumic and elderly patients. Etomidate has hemodynamic stability. There is no significant effect on the peripheral and pulmonary vascular bed and on myocardium. The possibility of aspiration with Etomidate is more due its side effect of nausea and vomiting. Material and Methods:Total 100 patients of ASA Grade I and II between age of 30 and 65 years undergoing surgery under general anaesthesia were studied. Patients were divided into 2 groups of 50 patients each. Etomidate group (n=50): received Inj. Etomidate 0.3 mg/kg intravenously. Propofol group (n=50): received Inj. Propofol 2.0 mg/kg intravenously. Results:Propofol produced decrease in arterial pressure at 1 to 3 minutes after induction which failed to come to baseline reading after laryngoscopy and intubation while Etomidate produced less fall just after induction and showed slight rise after laryngoscpy. The heart rate changes were almost similar in both the groups. The incidence of pain at injection site was more in Propofol group. There was high incidence of Myoclonus in Etomidate group. Conclusion:In present study we find that Propofol causes decrease in arterial pressure at induction which fails to return to baseline after laryngoscopy and intubation while Etomidate produces less degree of fall with slight rise after laryngoscpy. There is no difference in heart rate changes in both groups. The incidence of pain was more in Propofol group than in Etomidate group. There was a higher incidence of Myoclonus in Etomidate group; this was not observed in Propofol group.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

COMPARISON OF ETOMIDATE AND PROPOFOL AS INDUCTION AGENT IN G.A., KANHAIYA LAL KISHNANI, SHAILESH MISHRA, SANJAY. P. DAVE INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-8 | Issue-8 | August-2019

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