Volume : III, Issue : I, January - 2014

Comparison of Fentanyl and Lignocaine for Attenuation of Cardiovascular Stress Response to Laryngoscopy and Endotracheal Intubation

Dr Rupal B. Shah, Dr Gargi M. Bhavsar, Dr Happy R. Ghetia, Dr Manisha V. Thakkar, Dr Sumegh N. Prajapati

Abstract :

AIM To compare Fentanyl and Lignocaine for:

· Effectiveness in attenuating the sympathetic response to laryngoscopy and intubation.

· Possible side-effects and complications in peri-operative period.

MATERIAL AND METHODS 40 patients of ASA grade I and II aged 20-50 years were selected for elective surgery requiring general anaesthesia for endotracheal intubation.

They were divided into 2 groups

Group-1: Lignocaine hydrochloride group. Here patients received inj. Lignocaine hydrochloride 1.5 mg/ kg i.v. bolus 3 min prior to induction.

Group-2: Fentanyl citrate group. Here patients received injection Fentanyl citrate 2 mcg/kg i.v. bolus 3 min prior to induction.

All patients were pre-oxygenated with 100% O2 for 3 min before induction. Induction was achieved with injection Thiopentone sodium 5 mg/kg i.v. and injection succinylcholine 2 mg/kg was given i.v. IPPV given with 100% O2 and after adequate relaxation laryngoscopy and intubation was done. Anaesthesia was maintained with O2(33%), N2O(67%), Isoflurane(0.5-1.0%) and injection Vecuronium omide. Peri-operative vitals and complications were recorded. Reversal was achieved with injection Neostigmine 0.05 mg/kg i.v. and injection glycopyrollate 0.004 mg/kg i.v.

RESULTS AND SUMMARY Changes in mean pulse rate and MAP was significant after intubation and intraoperatively with mean pulse rate, MAP being higher in group-1 than group-2. Thus Fentanyl citrate provides better haemodynamic stability by increasing sedation, analgesia and depth of anaesthesia.

CONCLUSION Fentanyl citrate is safer and more effective in attenuation of haemodynamic response to laryngoscopy and intubation.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Dr Rupal B. Shah, Dr Gargi M. Bhavsar, Dr Happy R. Ghetia, Dr Manisha V. Thakkar, Dr Sumegh N. Prajapati Comparison of Fentanyl and Lignocaine for Attenuation of Cardiovascular Stress Response to Laryngoscopy and Endotracheal Intubation International Journal of Scientific Research, Vol.III, Issue.I January 2014

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