Comparison of Granisetron versus Granisetron plus Dexamethasone after Laporoscopic Surgery

Dr. K.Venkateswara Rao; Dr .U.Swarnalatha

Volume : V, Issue : XI, November - 2016

Comparison of Granisetron versus Granisetron plus Dexamethasone after Laporoscopic Surgery

Dr. K. Venkateswara Rao, Dr . U. Swarnalatha

Abstract :

Postoperative nausea and vomiting, are relatively common after both general and regional anaesthesia. Most of the published trials indicate an improved antiemetic prophylaxis when using a combination of agents acting at different receptor sites, compared with monotherapy. We studied the efficacy of a combination of two antiemetic drugs like Granisetron and Dexamethasone in preventing PONV, after laparoscopic cholecystectomy which has a high incidence of PONV. AIMS & ABJECTIVES: PRIMARY OBJECTIVE: To compare the effectiveness of Granisetron and Dexamethasone, with Granisetron alone, for prevention of PONV after laparoscopic cholecystectomy. SECONDARY OBJECTIVES: To determine any adverse effects in the postoperative period. MATERIAL & METHOD: Data was collected from 60 ASA I and II patients scheduled for laparoscopic cholecystectomy aged between 20–60 years at ASRAM Medical College Hospital, Eluru.. INCLUSION CRITERIA Patients with ASA grade 1 and 2 and patients in the age group between age group 20–60 years were included in the study. EXCLUSION CRITERIA Patients with documented hypersensitivity to any of the study drugs, patients with history of motion sickness or previous PONV, patients who are pregnant or menstruating, patients who have taken antiemetic drugs within 24 hours before surgery and patients with history of neurological or renal diseases were excluded in our study. METHODS ?e study was a prospective, randomized, double blinded one. Patients were randomly allocated into two groups. 1)?ose who received i.v. Granisetron alone (40mcg/kg).(Group G) 2)?ose who received i.v. Granisetron(40mcg/kg) and i.v. Dexamethasone 8mg. (Group G plus D) ?e drugs were given intravenously 5 minutes before induction. Postoperatively all episodes of PONV experienced by the patient during the first 24 hours after anaesthesia, were recorded by direct questioning. Rescue Antiemetic (Metoclopramide 10mg) was used if patient had nausea or vomiting. CONCLUSION: ?e combination (Granisetron plus Dexamethasone) was found to be better in attaining a complete response than Granisetron alone and also adverse effects were less in G+D group than G group. Need for rescue antiemetic is more in Group G compared to group G + D