Comparison of prophylactic Ondansetron alone and Dexamethasone with Ondansetron to reduce Post-Operative Nausea and Vomiting (PONV) after Laparoscopic Cholecystectomy.

Archana Har; Sk Samim Ferdows; Vikrant Gadkari; Dr Amit Rai

Volume : VIII, Issue : XII, December - 2019

Comparison of prophylactic Ondansetron alone and Dexamethasone with Ondansetron to reduce Post-Operative Nausea and Vomiting (PONV) after Laparoscopic Cholecystectomy.

Archana Har, Sk Samim Ferdows, Vikrant Gadkari, Dr Amit Rai

Abstract :

Introduction: Laparoscopic Cholesystectomy is removal of Gall Bladder through abdominal ports which is appreciably associated with postoperative nausea & vomiting (PONV) resulting in increased morbidity and discomforts after the surgery in quite a number of patients. Our study was aimed to compare the efficacy of Ondansetron plus Dexamethasone and only Ondansetron as an antiemetic 30 minutes prior to elective laparoscopic Cholecystectomy. Methods: In this randomised double blind study, 80 patients of both sexes of ASA I and II aged between 16 to 60 yrs received 4 mg Ondansetron (Group C, n = 40), Ondansetron 4 mg plus Dexamethasone 8 mg (Group T, n=40) intravenously half an hour before induction of general anaesthesia. Peri operative care was standardised in all patients. Patient was then observed for 24 hours postoperatively for any episode of PONV and any adverse effects of the study drugs. Results: A complete response (defined as no PONV and no need for another antiemetic) was achieved in 62% of the patients receiving Ondansetron only and 85% of patients receiving Ondansetron plus Dexamethasone (P<0.05). The overall cumulative incidences (0–24 hrs) of PONV were 64% in Ondansetron only group, 36% in combination group (P<0.05). No difference in adverse events was observed in between group. Conclusion: We concluded that combination of Ondansetron plus Dexamethasone is better than Ondansetron alone as an antiemetic prophylaxis for PONV following laparoscopic cholecystectomy.