Comparison of the analgesic and hemodynamic effects of intrathecal ropivacaine with dexmedetomidine in lower limb surgeries

Dr Vikas Singh; Dr. Mohd. Imran; Dr Dinesh Kaushal

Volume : IV, Issue : I, January - 2015

Comparison of the analgesic and hemodynamic effects of intrathecal ropivacaine with dexmedetomidine in lower limb surgeries

Dr Vikas Singh, Dr. Mohd. Imran, Dr Dinesh Kaushal

Abstract :

Objective: To compare the analgesic and hemodynamic effects of intrathecal with dexmedetomidine in lower limb surgeries. Methods: Patient aged 18-50 years belonging to ASA physical status 1 or 2 planned for lower limb surgery were included in this study. On the basis of computer generated random table, patients were divided in to following two groups (25 in each): Group R+D was given intrathecal dexmedetomidine (3ml of ropivacaine 0.5% plus 3mic.gm dexmedetomidine intrathecally) and Group R had been the control group. Results: On comp�, the age, sex, height, weight and ASA grade of the groups were found similar i.e. did not differed significantly (p>0.05). The mean HR in Group R and R+D increased just after the surgery while in Group R+D, it remains almost similar to baseline. The mean MAP in Group R increased just after the spinal anesthesia while mean MAP in group R+D remained similar as compared to baseline. The mean time to achieve T10 sensory block lowered significantly in Group R+D (p<0.001) as compared to Group R. There was significant difference in the mean intra-operative VAS (p=0.01) and maximum sedation (p<0.001) between both the groups. A significantly difference in time to 1st analgesic requirement (p<0.001) and the time to 1st analgesia requirement was observed in both the groups. Not much difference was observed in the proportion of adverse effects between the groups. Conclusion: Our study establishes dexmedetomidine as superior drug as an adjunct to intrathecal ropivacaine 0.5% for patients undergoing lower limb surgery as it provides faster onset of anesthesia, better intraoperative and postoperative analgesia and prolonged duration of motor and sensory blockade without significant increase in adverse effects.