COMPARITIVE STUDY BETWEEN PHENYLEPHRINE Vs EPHEDRINE IN CONTROLLING SPINAL HYPOTENSION IN CAESAREAN SECTION

Dr.Shringarpure Swapnaja S; Dr.Mathai Kusuma; Dr.Nishkala C.

Volume : V, Issue : VIII, August - 2016

COMPARITIVE STUDY BETWEEN PHENYLEPHRINE Vs EPHEDRINE IN CONTROLLING SPINAL HYPOTENSION IN CAESAREAN SECTION

Dr. Shringarpure Swapnaja S, Dr. Mathai Kusuma, Dr. Nishkala C.

Abstract :

OBJECTIVE : The aim of this study was to compare efficacy of bolus ephedrine Vs Phenylephrine for maintainance of arterial pressure during spinal anaesthesia in cesarean section and also to not any adverse effects of them in mother or the foetus. MATERIALS AND METHODS : A double blind prospective randomized control study was carried out on 100 Female patients with singleton, full term, pregnancy undergoing elective as well as an emergency Caesarean section of ASA PS 1 and 1 �E� in the department of Obstetrics at Southern Railway Headquarters Hospital, Permabur, Chennai between January 2008 to December 2011. Using computer generated random numbers they were divided into 2 groups – Group 1(n= 50)patients receiving 6 mg ephedrine as bolus dose for correction of spinal hypotension . Group 2(n= 50 ) patients receiving 50 mcg of phenylephrine as bolus dose for correction of spinal hypotension . Whenever hypotension (fall in systolic BP more than 20–30%of baseline or BP less than 90 mmHg ) occurs the prefixed (1ml) dose of study drug was administered by I.V. bolus. Number of boluses & time taken to revert hypotension (B.P. > 90 mm of hg) recorded & were analysed with different statistical methods and tests. RESULTS : All the continous data were presented by mean with standard deviation and it was analysed with the help of Independent t–test. CONCLUSION : We found that both the vasopressors namely phenylephrine and ephedrine are equally effective in IV bolus form in maintenance of maternal arterial pressure within 20% limit of baseline values, though phenylephrine group required less number of boluses. Phenylephrine caused reactive hypertension which was statistically significant in our study, so it is prudent to take precautionary measures in an already hypertensive patient while using phenylephrine as a vasopressor. Both the vasopressors had no significant adverse effects on neonatal outcomes.