COMPARITIVE STUDY OF ANTI ULCER EFFECT OF ALOE VERA, OMEPRAZOLE AND RABEPRAZOLE IN ASPIRIN INDUCED PEPETIC ULCERS IN GUINEA PIGS.

Dr. ASHUTOSH KUMAR SINGH; B. KAVITHA

Volume : III, Issue : X, October - 2014

COMPARITIVE STUDY OF ANTI ULCER EFFECT OF ALOE VERA, OMEPRAZOLE AND RABEPRAZOLE IN ASPIRIN INDUCED PEPETIC ULCERS IN GUINEA PIGS.

Dr. Ashutosh Kumar Singh, B. Kavitha

Abstract :

Comparitive study of anti–ulcer effect of Aloe vera, Omeprazole and rabeprazole in Aspirin induced peptic ulcers in guinea pigs. SUB TITLE: To study and compare the anti ulcer effect of Aloe Vera, Omeprazole and Rabeprazole in Aspirin induced peptic ulcers in Guinea pig. SUMMARY: This study was performed to compare the Anti–ulcer effects of Aloe vera, Omeprazole & Rabeprazole on Aspirin induced peptic ulcers in Guinea pigs of either sex weighing between 400 – 600 gm were randomly allotted into four groups with six animals each. Aspirin 200 mg/kg– body weight was administered orally and kept fasting for 6 h. A. vera powder was mixed with gum acacia, the solution was administered orally through the oral gavage to guinea pigs in the dose of 200 mg/kg. Omeprazole 3.5mg/ Kg, Rabeprazole 2.5–mg/kg body weight was administered orally as a standard drug for present study. At the end of the study, ulcer index were studied. The significance of difference between means of control and treated groups were determined by one– way analysis of variance (ANOVA) test.