CONCURRENT CISPLATIN 5FU BASED CHEMOTHERAPY AND RADIOTHERAPY IN ADVANCED MUCOSAL SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK

Volume : VII, Issue : VI, June - 2018

Dr. K. Mahalakshmi Prasad, Dr. A. Jagadish Singh

One hundred and thirty four patients with locally advanced head and neck squamous cell carcinoma were prospectively studied from June 2012 –

May 2013 at Department of radiotherapy , Govt Rajaji Hospital and Madurai Medical College. All patients received concurrent Cisplatin + 5FU

based chemotherapy(CT) along with standard radiotherapy(RT).The initial complete response (CR) was 71 % and partial response was achieved in

rest 29% of the cases. The 4 yrs locoregional control was 45% for those patients who achieved complete response . Acute treatment related

toxicities included one death due to renal damage . The late toxicities noticed were xerostomia in 40% of patients. The results justify that

concomitant use of cisplatin + 5FU based chemotherapy along with radiotherapy is a effective and accepted standard of care in locally advanced

head and neck cancer patients in tertiary care centre.