Volume : II, Issue : X, October - 2013

Contribution of Stem Cells to Renal Ischemia Repair

Zahran F, El Ghareb M, Hamed S, El Naggar I

Abstract :

Background: The potential role of stem cells in the repair of glomerular and tubular injury is under intensive investigation. Several studies have addressed the role of endogenous bone–marrow (BM)–derived stem cells (SC) in the repair of renal injury.Materials and Methods: MSCs were cultured and rats were used as a common I/R model to induce Acute renal failure (ARF) by clamping both renal pedicles for 45 minutes then stem cells were transplanted.Ki–67 was used as marker for regeneration of renal tubulointerstitial injury. Results: shows increase in regeneration in renal tubulointerstitial in treated animals with MSCs more than untreated animals (control +ve). Conclusion: MSCs may be useful in treatment of renal ischemia and it can use as therapy of AKI.

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Zahran F, El-Ghareb M, Hamed S, El-Naggar I / Contribution of Stem Cells to Renal Ischemia Repair / International Journal of Scientific Research, Vol.2, Issue.10 October 2013

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