CORRELATION BETWEEN 25–HYDROXYVITAMIN D AND SEVERITY OF PARKINSON‘S DISEASE

Dr. Ghanshyam Sharma; Dr.Ramgopal Ghritlahare; Dr Brajendra Kumar

Volume : VIII, Issue : IV, April - 2019

CORRELATION BETWEEN 25–HYDROXYVITAMIN D AND SEVERITY OF PARKINSON‘S DISEASE

Dr. Ghanshyam Sharma, Dr. Ramgopal Ghritlahare, Dr Brajendra Kumar

Abstract :

The present study is aimed to determine the associations of circulating 25–hydroxyvitamin D (25OHD) levels with the severity of PD. In 109 patients, the severity of PD was evaluated by using Hoehn & Yahr (HR) stages and Unified Parkinson�s Disease Rating Stage (UPDRS) Part III compared with 25OHD level in a double–blind and cross–sectional study. Mean � SD levels of 25OHD were 28.5 � 1.4 and 27.1 � 1.5, for males and females, respectively. Also, 38.4% of the patients showed deficiency levels of 25OHD (<20 ng/mL), and 72.8% had insufficient levels (<30 ng/mL). High prevalence of 25OHD insufficiency in subjects with early disease was not associated with HR stage and UPDRS scores even after multivariate adjustment for possible confounders including disease duration. These findings are consistent with the possibility that vitamin D status does not seem to deteriorate during the early disease stages of PD.