CORRELATION OF 1H MR SPECTROSCOPY METABOLITES LEVEL IN BILATERAL BASAL GANGLIA WITH CLINICAL STATUS AND OUTCOME IN PATIENTS OF MILD AND MODERATE TRAUMATIC BRAIN INJURY

DR VERMA SIDDHARTH; DR SHANKAR KB; DR SHARMA KC

Volume : VII, Issue : XI, November - 2018

CORRELATION OF 1H MR SPECTROSCOPY METABOLITES LEVEL IN BILATERAL BASAL GANGLIA WITH CLINICAL STATUS AND OUTCOME IN PATIENTS OF MILD AND MODERATE TRAUMATIC BRAIN INJURY

Dr Verma Siddharth, Dr Shankar Kb, Dr Sharma Kc

Abstract :

Traumatic ain injury(TBI) is one of the major causes of morbidity and mortality. MR Spectroscopy provides a measure of cereal metabolite levels. METHODS: A total of 45 patients with mild to moderate TBI were included over the period of 17months. Ratios of NAA/Cr, Cho/Cr & NAA/Cho (metabolites level) were correlated with clinical status (using Glasgow Coma Scale) and outcome after 3 months (using Glasgow Outcome Score) at B/L basal ganglia level. RESULTS In our study patients age ranged from 20 to 60 years.¹H MR spectroscopy was performed during sub acute period (mean 7–15 days). Metabolite ratios of NAA/Cr, Cho/Cr & NAA/Cho at bilateral basal ganglia did not show any correlation with Glasgow coma scale (p=0.61,p=0.18,p=0.24 respectively) however, statistically significant correlation exists with Glasgow Outcome Score (p<0.0001). CONCLUSION:¹HMR spectroscopy of bilateral basal ganglia did not show any correlation with clinical status but significant correlation exists with Glasgow Outcome Score (GOS).