CORRELATION OF HYPOXIA INDUCIBLE FACTOR1Î± LEVELS WITH DISEASE STATUS IN ORAL SQUAMOUS CELL CARCINOMA

Jitender Prasad; Binita Goswami; Kiran Agarwal; Pravesh Mehra; Shilpa Kumar; Bindiya K Pahuja; Anju Chauhan; Ashok Ahirwar

Volume : VI, Issue : III, March - 2017

CORRELATION OF HYPOXIA INDUCIBLE FACTOR1Î± LEVELS WITH DISEASE STATUS IN ORAL SQUAMOUS CELL CARCINOMA

Jitender Prasad, Binita Goswami, Kiran Agarwal, Pravesh Mehra, Shilpa Kumar, Bindiya K Pahuja, Anju Chauhan, Ashok Ahirwar

Abstract :

Introduction: oral squamous cell carcinoma (OSCC) is a major health problem in our country. the increasing incidence of youth dependence on tobacco , pan masala and gutka, which are known pre disposing factors have further aggravated the problem. Intra tumoral hypoxia activates a number of adapting pathways such as the Hypoxia Inducible Factor–1 α (HIF–1 α) which confers a survival advantage to the tumour cells. The present study was carried out to evaluate the association of HIF–1 expression with disease aggressiveness. Material & Methods: The study comprised of 50 histologically proven cases of oral SCC and 50 healthy controls. The HIF –1 α levels were measured by commercially available ELISA in the blood samples. The data was analysed using SPSS software version 20. Results: The HIF–1α levels were found significantly higher in the patients with aggressive disease regarding the histological grading of differentiation and the stage at presentation. Conclusions: Our findings prove that higher HIF–1 α levels indicate advanced state of the disease and consequent poor prognosis.