IJSR - International Journal of Scientific Research

Dr. Muktanjalee Deka; Dr. Pioja Pegu

Volume : VIII, Issue : VIII, August - 2019

Correlation of p53 expression by Immunohistochemistry with Grade and Nodal status in Oropharyngeal Squamous Cell Carcinoma of Gauhati Medical College – 2 years retrospective study

Dr. Muktanjalee Deka, Dr. Pioja Pegu

Abstract :

Backround & objectives: Squamous cell carcinoma is the most common oral cancer. p53 overexpression has a prognostic signifance on Oropharygeal Squamous cell Carcinoma(OPSCC).The current study has been undertaken to correlate hislogical grades, p53 expression and its correlation with lymph node metastasis. Methods: Histopathologically diagnosed 32 cases of Oropharygeal Squamous cell carcinoma during a period of 2 years in the Department of Pathology, Gauhati Medical College & Hospital were included in the study and immunohistochemistry was performed with p53. All the cases were graded according to Broder’s system. Results: Of the Oropharygeal squamous cell carcinoma, 53.1% showed p53 positivity. Mean labelling index of Poorly differentiated > moderately differentiated > well differentiated. P53 positivity rate in patients with lymph node metastasis was 84.6% , which is significantly higher than that in the patients without lymph node metastasis (31%).Out of 32 cases 13(40%) had cervical lymph node metastasis. Conclusion: This study concludes that p53 positivity is significantly associated with the histological grades and lymph node metastasis in OPSCC. So can be used as a significant prognostic marker for OPSCC.