Correlation of serum HbA1c level,Age of patient & DM duration with Central Macular Thickness by OCT in Diabetic Macular Edema

Dr.Jitendra Kumar; Dr.Arti Kushwaha

Volume : VII, Issue : VII, July - 2018

Correlation of serum HbA1c level,Age of patient & DM duration with Central Macular Thickness by OCT in Diabetic Macular Edema

Dr. Jitendra Kumar, Dr. Arti Kushwaha

Abstract :

Purpose To evaluate the correlation between glycosylated haemoglobin (HbA1c) and central macular thickness as measured by optical coherence tomography (OCT) in patients with diabetes.Methods Observational study of central macular thickness as measured by OCT and laboratory data of glycosylated haemoglobin. HbA1c was compared with central macular thickness measured by OCT within the preceding 3months. Clinically significant macular edema (CSME) was diagnosed if central macular retinal thickness was greater than325 �m in OCT.Results One hundred and two eyes of 102 patients were included in this cross–sectional study. The analysis revealed that the CSME diagnosed by OCT in diabetes was not statistically significant with sex, right or left eye, DM duration > 10 years or not, and AC sugar level (> 140 or not). The HbA1C level(≥8) and age (≤50) showed a significant (P=0.005 and 0.006, respectively)and positive association with macular thickness in OCT. A trend towards higher risk was seen for factors of age ≤50 and HbA1c≥8%.Conclusions Patients with HbA1c of ≥8 had an increase in macular thickness in type 2 diabetic eyes and there was a statistical significant correlation between younger age,shorter DM duration and thicker macular thickness. Strict sugar control decreased the risk of diabetic macular retinopathy, and OCT could be an excellent detector of early diabetic macular oedema.