Crystallize to Definitize Cancer.

Dr. Hina Mehrotra; Dr. Heena Sadiq; Dr Rubeena Anjum; Dr. Pragya Goyal; Dr. Pooja Kasana; Dr. Shahid Masood shaikh

Volume : VI, Issue : X, October - 2017

Crystallize to Definitize Cancer.

Dr. Hina Mehrotra, Dr. Heena Sadiq, Dr Rubeena Anjum, Dr. Pragya Goyal, Dr. Pooja Kasana, Dr. Shahid Masood Shaikh

Abstract :

AIM: To determine the pattern of the crystallization of cupric chloride for screening of OSCC and to find out the correlation, if any, between number of Transverse Form (TF) and clinical and histopathological grades of OSCC

Materials and Methods: Thirty three diagnosed patients of OSCC and 10 healthy individuals were selected. One drop of blood was mixed into 1 cc of distilled water at room temperature to give a final dilution of 6% hemolyzed blood. 0.1 to 0.2 cc of blood sample was then subjected to crystallization test by adding 10cc of 20% cupric chloride solution at room temperature.

Results: In healthy control group, the typical pattern was an eccentrically placed centre of gravity with needles arranged in radiating fashion, while in OSCC group, there was �transverse form� (TF) formation. The sensitivity and specificity of this test was found to be 95% and 96%, respectively.The positive and negative predictive values were found to be 97.96% and 98.55%,

respectively. The mean TF frequency was found to be increasing from grade I (3.20 � 1.5%) to grade II (653 � 2.23%) and difference was statistically significant (P = 0.0001). However, there was no correlation between mean TF frequency and TNM stages of OSCC.

Conclusion: It is a simple, economical, reliable, test which is less time–consuming and less invasive screening procedure. It can be used for early detection of OSCC and also used to screen all cancer cases of OSCC. Early detection of cancer is possible even before biopsy in suspected cases. Biopsy should be advised in the positive cases.