Volume : VI, Issue : XII, December - 2017
CUTANEOUS MANIFESTATIONS OF INTERNAL MALIGNANCIES – A STUDY OF 217 CASES
Dr. S. Srinivasa Ravi, Dr. Anusha Pilla
Abstract :
BACKGROUND :
Skin manifestations act as markers for internal malignancy. There may be direct and indirect involvement of skin in various malignancies. Cutaneous manifestations may act as early markers for internal malignancy and various skin manifestations both specific and non specific were seen during the course of malignancy.
AIM :
The main purpose of this study is to know the incidence and clinical pattern of skin changes both specific and non specific seen in various internal malignancies.
MATERIALS AND METHODS :
It is an open prospective and observational study. All confirmed malignancy cases attending to the Out patient departments of Radiotherapy and DVL at Government General Hospital, Kakinada were recorded over a period of one year from MAY 2005 to MAY 2006. Total 217 cases of various malignancies were seen during the above period. These cases were clinically evaluated for skin manifestations and the demographic data was noted. These cases were thoroughly clinically examined for various skin manifestations. Relevant haematological, biochemical investigations and skin biopsies were taken in some cases.
RESULTS :
Out of 217 cases, skin changes were seen in 74 out of 217 cases and the incidence is 34.1 %. Specific skin changes were observed in 10 cases ( 4.6 %) and non specific lesions were observed in 64 cases ( 29.5%)
The specific manifestations were Cutaneous metastasis ( primary being Lymphomas ) in the form of nodules in three cases, Acanthosis nigricans in one case of Adeno carcinoma of stomach, Paraneoplastic pemphigus (primary malignancy being Lymphoma) in one case, Ichthyosis acquisita in one case of Lymphoma, one case of Paget’s disease of east associated with intraductal carcinoma of east , one case of Neutrophilic dermatosis with Lymphoma , one case of Xeroderma pigmentosum with Acute myeloid leukemia and one case of Pyoderma gangrenosum with Rectal carcinoma The non specific changes were Generalised pruritus, Herpes zoster, Diffuse alopecia, Vitiligo, Tinea versicolor, Ichthyosis vulgaris etc.
CONCLUSION :
In this study, the following observations were made. Cutaneous secondaries were the most common cutaneous manifestation with internal malignancies. Non Hodgkin’s lymphoma is the most common internal malignancy associated with cutaneous manifestations.
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DOI : 10.36106/ijsr
Cite This Article:
DR.S.SRINIVASA RAVI, DR.ANUSHA PILLA, CUTANEOUS MANIFESTATIONS OF INTERNAL MALIGNANCIES – A STUDY OF 217 CASES, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-6 | Issue-12 | December-2017
Number of Downloads : 225
References :
DR.S.SRINIVASA RAVI, DR.ANUSHA PILLA, CUTANEOUS MANIFESTATIONS OF INTERNAL MALIGNANCIES – A STUDY OF 217 CASES, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-6 | Issue-12 | December-2017
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