Cytogenetic studies in abortus foetuses of TORCH positive mothers experiencing Bad obstetric history

JISHA.P; DR.D.DINESH ROY; DR.ARUN.B

Volume : VIII, Issue : V, May - 2019

Cytogenetic studies in abortus foetuses of TORCH positive mothers experiencing Bad obstetric history

Jisha. P, Dr. D. Dinesh Roy, Dr. Arun. B

Abstract :

During gestation, the microorganisms causing severe birth defects and the resulting clinical syndrome have been categorized as TORCH infections which includes Toxoplasmosis, others (syphilis, varicellla–zoster, parvovirus B19), Rubella, Cytomegalovirus (CMV) and Herpes infections. Hence the present study was undertaken to investigate the role of maternal infections (TORCH) and the incidence of foetal chromosome anomalies. Aborted fetuses of T0RCH positive mothers were selected for this study. The foetal blood samples were collected from all aborted fetuses of mothers with TORCH IgM/IgG antibodies. Genetic study was carried out in aborted fetuses of fifty five TORCH positive mothers. Among 55 aborted cases 45 (82%) showed normal karyotype and the rest 10(18%) showed abnormal karyotype. The study revealed that the incidences of foetal chromosomal abnormalities were increased with increased age of women. Among TORCH positive cases maximum abnormal karyotype were observed among CMV infected cases followed by Rubella. Karyotype abnormality was found to be elevated if the mother was positive for CMV and any other infections. Least abnormalities were observed among Toxoplasma positive cases. The increased incidences of foetal chromosome abnormalities among the TORCH positive subjects strongly recommend for prenatal screening and genetic counseling to the parents before the next pregnancy.