DESIGN, CHARACTERIZATION AND IN–VITRO EVALUATION OF SEROTONIN AND ADRENALINE SELECTIVE NEUROTRANSMITTER UPTAKE INHIBITOR DULOXETINE HYDROCHLORIDE: A THIOPENE DERIVATIVE IN TO FLOATING TABLETS

Dr P SHASHIDHAR; Dr D RAMAKRISHNA; Dr M SUNITHA; Ms. ARSHIYA FATIMA

Volume : VI, Issue : XI, November - 2017

DESIGN, CHARACTERIZATION AND IN–VITRO EVALUATION OF SEROTONIN AND ADRENALINE SELECTIVE NEUROTRANSMITTER UPTAKE INHIBITOR DULOXETINE HYDROCHLORIDE: A THIOPENE DERIVATIVE IN TO FLOATING TABLETS

Dr P Shashidhar, Dr D Ramakrishna, Dr M Sunitha, Ms. Arshiya Fatima

Abstract :

In the present study duloxetine hydrochloride is formulated into gastro retentive tablet dosage form–(floating tablets), duloxetine hydrochloride is a thiopene derivative; it acts as a serotonin and adrenaline selective neurotransmitter uptake inhibitor. Based on the FTIR compatibility between the drug and polymers and review of literature an attempt was made to prepare floating tablets of the drug, where sodium alginate, klucel HXF, Methocel K100 were selected as release retarding agents. Total 14 trials were made, of which sodium alginate and klucel HXF were used till trial T–4, and then only klucel HXF was used till trialT–09 with varying concentrations. Drug release was satisfactory in trial T–09, but floating time, rate of tablet disintegration was not satisfactory, to overcome this Methocel K100 in varying proportions was used to prepare trials from T–10 to T–14. Drug release was 94% in 8 hr. whereas buoyancy time was found to be 12 minutes and floating time was 11hr 45 min. release rate kinetics were also determined by interpreting the release of drug and time into various kinetic models, the order of release was found based on regression coefficient value (R²–value), was found to be 0.989, 0.826, 0.959 and 0.993 and order is as 0.993 KORESMEYER PEPPAS PLOT > 0.989 ZERO ORDER > 0.959 HIGUCHIS PLOT > 0.826 FIRST ORDER..