Detection of ESBL producing Klebsiella species in Burn Patients and their Antimicrobial Resistance Pattern

V. A. Kamble; M. G. Thosar

Volume : IV, Issue : II, February - 2015

Detection of ESBL producing Klebsiella species in Burn Patients and their Antimicrobial Resistance Pattern

V. A. Kamble, M. G. Thosar

Abstract :

Infection is a central cause of mortality in burns. There is a higher rate of nosocomial infections in burn wards. Among them Klebsiella has been found to be the common species to produce extended spectrum β-lactamases (ESBL). The present study was aimed to determine the prevalence of ESBL producing Klebsiella and their susceptibility pattern. A retrospective study from burn ward infected patients admitted to burn unit of Amravati and Akola district�s Government hospitals was carried out to determine the occurrence and resistance pattern of ESBL producing Klebsiella species. Klebsiella species were isolated from 214 burn wound swabs taken from burn patients and identified by conventional biochemical methods and screened for ESBL production by phenotypic confirmatory disc diffusion test and antibiogram was tested. From 214 specimens, 130 Klebsiella species were isolated. Among them 117 isolates were identified as K. pneumoniae and 13 isolates were identified as K. oxytoca. ESBL production was detected in 18.46% of Klebsiella species. All (100%) ESBL positive Klebsiella isolates were found to be sensitive to Chloramphenicol and meropenem, while isolates were resistant to penicillins and cephalosporins classes of antibiotic. Klebsiella species were the common organism causing burn wound infection in the present study showing high resistance pattern against different classes of antibiotics, while drug of choice for therapy is limited and carbapenems was the most effective treatment option for ESBL producing Klebsiella infection.