Detection of failed thrombolysis by doing serial ECG & estimation of CPKMB levels and its comparison with Coronary Angiography

Dr Kumar Rajeev; Dr Abhilasha Rashmi

Volume : V, Issue : XII, December - 2016

Detection of failed thrombolysis by doing serial ECG & estimation of CPKMB levels and its comparison with Coronary Angiography

Dr Kumar Rajeev, Dr Abhilasha Rashmi

Abstract :

Background: ?is study is done to detect failed thrombolysis by doing serial ECG & estimation of CPK–MB levels. It is then compared to Coronary Angiography for confirmation. Methods: 28 out of40 patients of AMI were thrombolysed by Streptokinase and 12 were administered anticoagulant. >50% resolution of ST segment and Post/Pre thrombolysis/ anticoagulation CPK–MB Ratio was compared in both groups. Further, in study group, results were compared with that of angiography, to see the percentage of patients who underwent successful thrombolysis. Results: In study group, 57.1% showed >50% resolution of ST segment and 64.3% ≥10 times rise in CPK–MB after thrombolysis. In control group, 25% fulfilled ECG and 16.6% cardiac enzyme criteria after anticoagulation. Regarding confirmation of successful thrombolysis, 50% of study group showed TIMI Grade III Coronary blood flow in angiography. Conclusion: Post & pre thrombolysis ECG and CPK–MB levels seem to be a realistic strategy for assessing reperfusion failure. Such patients could then be considered for repeat thrombolysis or intervention.