Detection of Imipenem Resistant and Metallo beta lactamase producing Pseudomonas aeruginosa in a Tertiary Care Hospital.

Dr. Prachee Singh

Volume : VII, Issue : VII, July - 2018

Detection of Imipenem Resistant and Metallo beta lactamase producing Pseudomonas aeruginosa in a Tertiary Care Hospital.

Dr. Prachee Singh

Abstract :

Context– Pseudomonas aeruginosais acquiring drug resistance even with imipenem according to recent studies and therefore a study was required to know the drug resistance status in the area .

Aims:The objectives of the study are to isolate the imipenem resistant Pseudomonas aeruginosa and Metallo beta lactamase producing Pseudomonas aeruginosain tertiary care hospital

Methods and Material:200 isolates of Pseudomonas aeruginosa were studied. The colonies were tested for biochemical tests, identification was done and then put to Antibiotic susceptibility test and MBL confirmation done by combined disc method.

Results: It may be observed from the study that Pseudomonas aeruginosa have only 10.5% imipenem resistance and out of this only 23.80% strains were Metallo beta lactamase producers.The imipenem resistance and MBL producing Pseudomonas aeruginosa were found more prevalent in male patients. The imipenemresistane was observed maximum in 21–40 years age acket where as maximum MBL producers strains were detected in 41–60 years age of patients. Imipenem resistance was maximum found in the isolates drawn from surgery dept. whereas Urology dept. recorded highest percentage of MBL producer. Urine and Tissue specimens had maximum imipenem resistant isolates where as Blood samples were highest MBL producers in the study.

Conclusions: It may be concluded from the study that Pseudomonas aeruginosa have only 10.5% imipenem resistance in the area and out of this only 23.80% strains were Metallo beta lactamase producers. The age wise analysis of imipenem resistance and MBL producers may also provide an idea to clinicians .