DETERMINATION OF RBC MEMBRANE BOUND LIPID IN ATORVASTATIN TREATED HYPERLIPIDAEMIA PATIENTS BY THIN–LAYER CHROMATOGRAPHY

P. Sagunthala; Dr. K. Elangovan; Dr.S. Subramaniam; S. Shyama

Volume : VIII, Issue : VI, June - 2019

DETERMINATION OF RBC MEMBRANE BOUND LIPID IN ATORVASTATIN TREATED HYPERLIPIDAEMIA PATIENTS BY THIN–LAYER CHROMATOGRAPHY

P. Sagunthala, Dr. K. Elangovan, Dr. S. Subramaniam, S. Shyama

Abstract :

Statin medication is essential to treat hypercholesterolemia as well as for primary and secondary prevention of cardiovascular disease. Thin–layer chromatography (TLC) is a technique that has been routinely used for the separation and identification of lipids like cholesterol, Triglycerides, free fatty acids, phospholipids and free cholesterol. In this study, 40 mg of atorvastatin treated hyperlipidaemia patients showed a significantly decreased lipids levels. But, atorvastatin treatment has some adverse events like myalgia, myopathy and rhabdomyolysis and these adverse effects can be ameliorated by co–administration of coenzyme Q10 (CoQ10). The present study highlights the aspects of TLC–based lipid separations on RBC memance