Development of a New Spectrophotometric  Method for the Determination of Balofloxacin  in Tablet Dosage Forms

Shreya Nayak; Sanjay Pai P.N

Volume : II, Issue : VII, July - 2013

Development of a New Spectrophotometric Method for the Determination of Balofloxacin in Tablet Dosage Forms

Shreya Nayak, Sanjay Pai P. N

Abstract :

A simple and accurate visible spectrophotometric method was developed and validated for the determination of balofloxacin in bulk and marketed tablet dosage form using 1% w/v of ceric sulphate as chromogenic agent. The own coloured complex formed by cerium (IV) solution with balofloxacin was stable up to 30 min and was measured for absorbance at its λ max of 492nm.The Beers law concentration range was found to 10-100 �g/ml with good correlation coefficient of 0.9922. The method was optimized and validated for linearity, accuracy and precision. The validated method was accurate as found from recovery of 97.14 % to 98.88 % when applied for marketed tablet formulations.