Development of Carboplatin Drug Delivery System for Its Ocular Use

Sovan Sutradhar; Archita Katrolia; Velpandian T; VK Shukla

Volume : VIII, Issue : I, January - 2019

Development of Carboplatin Drug Delivery System for Its Ocular Use

Sovan Sutradhar, Archita Katrolia, Velpandian T, Vk Shukla

Abstract :

Carboplatin is platinum based anti–carcinogenic agent useful in the treatment of Retinoblastoma. Experiments have been performed to formulate ocular patch of carboplatin in order to enhance residual time and prolong drug release. Using gelatin, ocular inserts were prepared, mixed with water. After properly autoclaving the mixture, drug at different concentration were incorporated into the gelatin–water mixture, DMSO (Di–Methyl Sulfoxide) was used as a solubility enhancer. The cross linking was done by pouring glutaraldehyde (GTA) on to the formulation mixture and allow for drying overnight. The patches were then evaluated for uniformity of thickness, folding endurance, loss on drying, tensile strength and in vitro and ex vivo drug release study. Finally, LC–MS/MS (Liquid Chromatography– Mass Spectroscopy/Mass Spectroscopy) study was carried out to see the drug release kinetics (in vitro and ex vivo). By this study the researcher took an attempt to formulate a superior ocular drug delivery system with pronounced therapeutic efficacy, and to improve the penetration of Carboplatin in eye to give localized targeted effect.