Dexmedetomidine reduces minimum alveolar concentration (MAC) of isoflurane in patients undergoing lumbar laminectomy

Dr Wasim Mohammad Bhat; Dr Aatif Nabi Shah; Dr Basharat Ahad

Volume : IX, Issue : II, February - 2020

Dexmedetomidine reduces minimum alveolar concentration (MAC) of isoflurane in patients undergoing lumbar laminectomy

Dr Wasim Mohammad Bhat, Dr Aatif Nabi Shah, Dr Basharat Ahad

Abstract :

Background: Dexmedetomidine, an alpha–2 agonist used as an adjuvant in general anaesthesia, has anaesthetic sp� property. Aims: To study the effect of dexmedetomidine on requirement of isoflurane during general anesthesia with bispectral monitoring of depth of anaesthesia . Materials and Methods: One hundred patients were randomly divided into 2 groups of 50 each. In group F, fentanyl 2 mcg/kg was given while in group D, dexmedetomidine was given intravenously as loading dose of 1 mcg/kg over 10 min prior to induction. After induction with propofol in group B, dexmedetomidine was given as infusion at a dose of 0.2–0.7 mcg/kg/hour. Isoflurane was used as inhalation agent in both groups. Hemodynamic variables, BIS and minimum alveolar concentration (MAC) of isoflurane were continuously recorded. Statistical analysis was done by unpaired student�s t–test and Chi–square test for continuous and categorical variables, respectively. p‑value < 0.05 was considered significant. Results: The use of dexmedetomidine was associated with a statistically significant decrease in MAC of isoflurane in group D (0.759�.012) as compared to group F (0.901�0.030). Conclusion: Dexmedetomidine decreases isoflurane requirement for maintaining adequate depth of anaesthesia.