Disintegration Behavior of Metronidazole Tablets Containing Different Ratios of Co-Processed Abelmoschus esculentus Gum and Manihot esculenta Starch.

Nnamani; D. Nnabuike; Oyeniyi; Y. James

Volume : VIII, Issue : II, February - 2019

Disintegration Behavior of Metronidazole Tablets Containing Different Ratios of Co-Processed Abelmoschus esculentus Gum and Manihot esculenta Starch.

Nnamani, D. Nnabuike, Oyeniyi, Y. James

Abstract :

This study examines the disintegration behaviour, over 3 months, of metronidazole tablets formulated with co–processed Abelmoschus esculentus gum to Manihot esculenta starch. The gum and starch were extracted from Abelmoschus esculentus fruits and Manihot esculenta tubers respectively. The gum and starch extracts were co–processed in 4 different ratios of gum to starch; 0.50:99.5, 1.00:99, 1.25:98.75 and 1.50:98.5. These 4 co–processed excipients, and standard microcrystalline cellulose, were used in formulating 5 different batches of metronidazole granules as disintegrant. The metronidazole granules from these batches were analysed for chemical compatibility and micrometric properties. The FT–IR analysis of the co–processed excipients and metronidazole showed no chemical incompatibility, and the granules exhibited good flow properties. The granules were compressed to tablets, and the tablets physicochemical properties determined and evaluated. The tablets all passed tablet per cent friability, hardness, and disintegration time tests. The dissolution of metronidazole from tablet after I hour was over 60 % for all the batches. The disintegration properties of the tablets over 3 months were then determined and statistically analysed. The two Way ANOVA analysis showed that the difference in disintegration time of the metronidazole tablets with different test excipients, after 3 months of storage is significant at 5 % level. It can be concluded that the different excipient combinations had different effect on disintegration time on storage. The metronidazole tablets formulated with 0.5:99.5 ratio of co–processed Abelmoschus esculentus gum and Manihot esculenta starch gave the best disintegration time as metronidazole formulated with standard microcrystalline cellulose disintegrant.