IJSR - International Journal of Scientific Research

Dr.Rina Barman; Dr.Ranjana Bandyopadhyay; Dr.Ujjwal Bandyopadhyay; Dr.Mounam Chattapadhyay; Prof(Dr) chhanda Datta

Volume : VIII, Issue : VIII, August - 2019

Distribution of hemoglobinopathies among patients attending haematology unit of a rural Government medical college of West Bengal, India–a single centre based study.

Dr. Rina Barman, Dr. Ranjana Bandyopadhyay, Dr. Ujjwal Bandyopadhyay, Dr. Mounam Chattapadhyay, Prof Dr Chhanda Datta

Abstract :

Β–thalassaemia is a heterogeneous group of inherited disorder of haemoglobin synthesis, characterized by a reduction of (β + ) or absence (β 0 ) of synthesis of beta globin chains of haemoglobin .Haemoglobinopathies are a group of genetic disorders of haemoglobin (Hb). Thalassemia syndromes are a heterogeneous group of single gene disorders, inherited in an autosomal recessive manner, prevalent in many parts of the world. Worldwide, 15 million people have clinically apparent thalassemic disorders.Prevalence of Hemoglobinopathies in West Bengal, India, is around 3.3%, although there are marked regional differences in incidence. The carrier rate for the β–thal gene varies from 1 to 3% in Southern India to 3 to 15% in Northern India.In this background of scientific knowledge the present study was conducted with aim to find out distribution of thalassaemia and other haemoglobinopathies in patients with anaemia attending haematology unit of a medical college. The present study analysed different fractions of hemoglobin of 2650 subjects attending the Haematology of a rural Medical College. It was seen that 22.71% of subjects had haemoglobin disorder and 77.29% of subjects were normal out of total 2650 subjects studied. Among screening group, the number of parental screening is maximum (44.52%) followed by suspect screening (30.74%) and then antenatal screening group(9.46%). In the 1yr to10yrs age group, the distribution of Beta thalassaemia major was 82%, that of HbE–Beta thalassaemia (47.70%) and HbS–Beta thalassaemia was found to be 47.06%. A high prevalence of Beta thalassaemia trait(42.29%) was noted in 20 yrs–30yrs age group followed by (23.60%) in 30yrs –40yrs age group.