Volume : V, Issue : V, May - 2016

Distribution pattern of chromosomal abnormalities in pediatric Acute Myeloid Leukemia: A study on 50 case from S.India

Prasannakumari, S. H. Mir Mazloumi, D. S. Madhumathi, L. Appaji

Abstract :

 A total of 50 pediatric Acute myeloid leukemia (AML )patients registered during the year 2009–2011 under 15 years of age were categorised into three groups and subjected for Cytogenetic and Fluorescence In Situ hyidization (FISH)study. 94% culture success rate was achieved. chromosomal abnormalities were detected in 32 patients(64%).The recurrent chromosomal abnormalities Viz., t(8;21)(q22;q22) in16 patients(50%), t(15;17)(q22;q21)in 5(15.6%) including a variant(15;17;22) (22;q21;q12) and del(16)(q22) /t(16;16)(p13;q22)/ inv(16) in in 4(12,5%) were observed. t(9;11), t(1;22), inv(3),which are rare abnormalities formed a small subgroup consists of three patients. The highest frequency of chromosomal abnormalities was observed in the age group of 10–15years. Chromosome 16 rearrangement was not detected by FISH in normal karyotype patients with CBFβ/ MYH11 probe. The frequency and prognostic value of the different karyotypes in the same group of patients were assessed.

Keywords :

Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Prasannakumari, S. H. Mir Mazloumi, D. S. Madhumathi, L. Appaji Distribution pattern of chromosomal abnormalities in pediatric Acute Myeloid Leukemia: A study on 50 case from S.India International Journal of Scientific Research, Vol : 5, Issue : 5 MAY 2016

Number of Downloads : 462

References :