Volume : III, Issue : VIII, August - 2014

DNA Mimicry by Proteins

Harikrishna Pillai, Harikumar, S. , Pramod Kumar, R. , Anuraj, K. S.

Abstract :

Most of the vital body functions are performed by the binding of enzymes to specific regions of DNA, for which it needs to recognize and bind to a target DNA sequence. This is controlled by another protein by direct obstruction of binding site, chemical modification of the binding site, indirect conformational change in the enzyme induced by the binding of the control protein or direct blocking of the DNA binding site on the protein by DNA mimicing. Proteins involved in DNA mimicry is a less explored field. Only a few proteins are reported to have this function which executes its application in a wide range of fields including detection of target DNA binding sites on enzymes and their isolation using the affinity methods. It can target bacterial restriction system, replication, repair and drug resistance, eventually finds it utility in diagnostic and even therapeutic uses of mimic in clinical settings. DNA binding proteins and enzymes are often difficult to crystallize for structural studies. It might be possible to use new DNA mimics, instead of the actual DNA molecule in the preparation of co-crystals aiding in elucidation of the DNA binding site on the target protein. Much more basic research is still to be performed in this area. This mini review details the proteins that function by DNA mimicry and their biological role .

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Article: Download PDF   DOI : 10.36106/ijsr  

Cite This Article:

Harikrishna Pillai, Harikumar, S., Pramod kumar, R., Anuraj, K.S. Dna Mimicry by Proteins International Journal of Scientific Research, Vol : 3, Issue : 8 August 2014

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