Volume : VI, Issue : X, October - 2017
Does exogenous progesterone exposure in early pregnancy increase the risk of intrahepatic cholestasis of pregnancy (IHCP) for, in vitro fertilization and embryo transfer (IVFET) conceptions?
Prof. Abha Majumdar, Dr. Sabina Sanan
Abstract :
.Objectives–
To compare the incidence of intrahepatic cholestasis of pregnancy in progesterone supported post IVF conception versus natural conception.
Material and methods–
Retrospective study. Participants were divided into two groups. Group A– 100 consecutive women (80 singleton and 20 twins) who conceived by IVF–ET and received progesterone support. Group B– 650 consecutive women (631 singleton and 19 twins) conceived naturally with no hormonal support.
Results–
In group A of 100 IVF conceptions, 29% (29/100) were diagnosed to have IHCP. Group B hasonly 4% (30/650) had IHCP.Twin gestations showed higher incidence of IHCP in both groups; 55% vs 22.5% in IVF conceptions and 47% vs 3.3% in natural conceptions respectively. Compå the incidence of IHCP within twin conceptions of the 2 groups, it was higher in IVF conceptions (55% vs 47%)
Conclusion
Increased incidence of IHCP has been found in IVF conceived pregnancies in which progesterone support is given, suggesting that progesterone may have a role in the onset of IHCP.Twin gestation itself can be a predisposing factor for IHCP.
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DOI : 10.36106/ijsr
Cite This Article:
Prof. Abha Majumdar, Dr. Sabina Sanan, Does exogenous progesterone exposure in early pregnancy increase the risk of intrahepatic cholestasis of pregnancy (IHCP) for, in vitro fertilization and embryo transfer (IVFET) conceptions?, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-6 | Issue-10 | October-2017
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References :
Prof. Abha Majumdar, Dr. Sabina Sanan, Does exogenous progesterone exposure in early pregnancy increase the risk of intrahepatic cholestasis of pregnancy (IHCP) for, in vitro fertilization and embryo transfer (IVFET) conceptions?, INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH : Volume-6 | Issue-10 | October-2017
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