Does TORCH serology have any role in evaluation of patients with bad obstetrics history (BOH)?

Dr.Jyoti Bade; Dr.Varsha Wanjare; Dr. Ameeta Joshi

Volume : V, Issue : VIII, August - 2016

Does TORCH serology have any role in evaluation of patients with bad obstetrics history (BOH)?

Dr. Jyoti Bade, Dr. Varsha Wanjare, Dr. Ameeta Joshi

Abstract :

Context:The present study was conducted to evaluate the utility of detection of IgM and IgG antibodies against TORCH (Toxoplasma gondii, Rubella, CMV and HSV) infections in women with BOH in order to reduce adverse foetal outcome.Settings and Design: The study included 150 women with bad obstetric history and 75 clinically normal pregnant women with previous normal full term deliveries. Serological evaluation for TORCH infections was carried out by IgM and IgG ELISA method.Results: In BOH cases IgM seropositivity for Toxoplasma was 18.67%., Rubella 32%, CMV 12.67% and HSV 6.67%. Maximum number of cases of abortion 37.33%, IUGR 25.33%, preterm labour 10.67%, early neonatal deaths 12% and congenital malformation 8% were associated with rubella infection. Intrauterine deaths were maximally associated with toxoplasma infection. IgG seropositivity for Toxoplasma 46.67%, Rubella 56%, CMV 90% and HSV 25.33%. This study showed an infection susceptibility of 80% to Toxoplasma, 73.33 % to Rubella, 38.67 % to CMV and 76 % to HSV in young adult women. It was assessed by estimation of TORCH specific IgG. Cross infection with more than one of the TORCH agent was observed. Conclusions: As the early treatment of infected pregnant women can prevent transmission of infection to foetus, early detection becomes very important.