DOWN SYNDROME: ASSOCIATION OF OXIDATIVE STRESS AND THYROID FUNCTION WITH HAEMATOLOGIC PROFILE

DR.RESHMI.R; DR.VIJAYALEKSHMI.M.T; DR.DINESH ROY .D; DR.GEETHA DAMODARAN

Volume : V, Issue : VII, July - 2016

DOWN SYNDROME: ASSOCIATION OF OXIDATIVE STRESS AND THYROID FUNCTION WITH HAEMATOLOGIC PROFILE

Dr. Reshmi. R, Dr. Vijayalekshmi. M. T, Dr. Dinesh Roy . D, Dr. Geetha Damodaran

Abstract :

Background:– Down syndrome (DS) or Trisomy 21 is the most common genetic cause of mental retardation . The phenotypic abnormalities and the morbidity in DS are due to higher gene dosage of chromosome 21, increased oxidative stress and thyroid dysfunction . Aims:– The association of oxidative stress and thyroid function with the haematological profile in DS was assessed.Methods and Material:–25 cases of Down syndrome was selected for the study after confirmation by karyotyping.6ml of blood was taken and send for haematological analysis and serum analysis of Malondialdehyde (MDA),Catalase ,Glutathione peroxidase, Uric acid, and Thyroid function. Statistical analysis used:–The mean and standard deviation of each of the variables were calculated . The association between the variables was calculated using Pearsons correlation. Results :DS cases showed significant increase of MCV ,significant decrease of WBC count, RBC count, Platelet count ,MCHC and neutropenia . The haematological variables showed a significant association with oxidative stress parameters . Conclusion :The haematologic profile in DS showed significant macrocytosis , anemia, leucopenia , neutropenia and thrombocytopenia.The increased oxidant stress in DS of this study, significantly altered the haematology of DS . Hence measures to decrease the oxidative stress may have a role in correcting the altered haematology profile in DS .