Drug Resistance pattern in new and previously treated cases of pulmonary tuberculosis patients at a tertiary care centre in Mumbai

Disha Sharma; Reena Set; Sheetal Bankar; Jayanthi Shastri

Volume : VIII, Issue : V, May - 2019

Drug Resistance pattern in new and previously treated cases of pulmonary tuberculosis patients at a tertiary care centre in Mumbai

Disha Sharma, Reena Set, Sheetal Bankar, Jayanthi Shastri

Abstract :

India has been identified as a hot spot region for multidrug resistant tuberculosis (MDR TB) infection. The objectives were to isolate and characterize Mycobacterium species isolated from cases of pulmonary TB, evaluate drug resistance patterns to first line drugs in isolates of Mycobacterium tuberculosis and to assess proportion of new and previously treated pulmonary TB patients with MDR TB. Materials and methods; The present study was an open labelled prospective study. The study was conducted for a period of one year from December 2015 to November 2016 on 250 patients. Two early morning sputum samples were collected and subjected to Ziehl Neelson staining and culture on LJ media. Results; The overall prevalence of pulmonary TB due to M. tuberculosis in the present study was 9.2%. The overall prevalence of drug resistance in the present study was 39.1%. The prevalence of MDR TB was 17.4%. Thirty percent of the previously treated cases were MDR TB, whereas none of the new cases were multidrug resistant.