EFFECT OF A SINGLE PRE–OPERATIVE DOSE OF DEXMEDOTOMIDINE VERSUS FENTANYL ON ANESTHETIC REQUIREMENT AND PERI–OPERATIVE HEMODYNAMIC STRESS RESPONSE

Dr. Richa Shah; Dr. Bina B Patel; Dr. Kalpana A Desai

Volume : VII, Issue : IX, September - 2018

EFFECT OF A SINGLE PRE–OPERATIVE DOSE OF DEXMEDOTOMIDINE VERSUS FENTANYL ON ANESTHETIC REQUIREMENT AND PERI–OPERATIVE HEMODYNAMIC STRESS RESPONSE

Dr. Richa Shah, Dr. Bina B Patel, Dr. Kalpana A Desai

Abstract :

Laryngoscopy is a part of intubation which leads to stress response. Dexmedetomidine and fentanyl attenuate stress response during laryngoscopy ,provide hemodynamic stability and reduce anesthetic requirements. Prospective randomized controlled study was carried out in 99 patients of ASA grade I and II, age group of 18–60 years, scheduled for surgery under general anesthesia. Patients were randomly divided in two groups.50 patients of group I received a single preoperative dose of dexmedetomidine 1�g/kg and 49 patients of group II received injection fentanyl 2�g/kg 10 minutes prior to intubation. Intraoperative pulse,blood pressure,spo₂,BIS value were recorded before induction,during laryngoscopy andintraoperatively till extubation.Adverse effects like nausea, vomiting, adycardia, hypotension were noted.We observed thatDexmedetomidine and Fentanyl reduce stress response during laryngoscopy.Dexmedetomidine reduces the usage of anesthetic requirements more as compared to fentanyl,hence provide smooth recovery without undue sedation.