Effect of Ascorbic acid on Lead nitrate induced Oligospermia in Albino Rats

Urvashi Singh; Priyanka Singhal; Hemant Ashish Harode

Volume : V, Issue : X, October - 2016

Effect of Ascorbic acid on Lead nitrate induced Oligospermia in Albino Rats

Urvashi Singh, Priyanka Singhal, Hemant Ashish Harode

Abstract :

Lead is the known environmental contaminant adversely affecting the male reproductive system in human and experimental animals. The cytotoxic effects of lead on male reproductive system involve the production of reactive oxygen species (ROS) and oxidative damage in tissue. Higher quantity of ROS in testicular tissue detrimentally affected the developing germ cell, which result in decrease sperm count. Supplementation of vitamin C causes partial recovery from oxidative stress and also causes increase sperm count. Five groups of animals were taken for the study i.e. control and four experimental. After 60 days of experimental period, rats were sacrificed and the testis along with epididymis was taken out for obtaining sperms. Sperm counting was done using Neubauer chamber. Sperm count was found to be decreased in lead nitrate treated groups as compared to control and found improvement in recovery group.