Effect of Blood 25–hydroxy vitamin D [25(OH)] levels on Prediabetes patients : A Meta–analysis of Randomised Control Trials

Rekha Choudhary; Prashant Hisalkar; Poorvi Gupta

Volume : VII, Issue : II, February - 2018

Effect of Blood 25–hydroxy vitamin D [25(OH)] levels on Prediabetes patients : A Meta–analysis of Randomised Control Trials

Rekha Choudhary, Prashant Hisalkar, Poorvi Gupta

Abstract :

Background: Emerging evidence suggests that vitamin D may play a role in the development of diabetes. This meta–analysis was done to evaluate effect of Vitamin D on blood glucose level among pre–diabetes patients. Objective: To evaluate the effect of vitamin D on glycaemic control in Prediabetes in different RCT performed. Methods: A literature search was conducted of MEDLINE, the Cochrane Liary, (CINAHL), Scopus, Web of Science through the reference lists of relevant articles until end of November 2017. Studies were included if they were RCT of vitamin D or vitamin D analogues in pre–diabetes. Treatment effect was estimated according to mean difference in the changes 2–h oral glucose tolerance test plasma glucose, fasting plasma glucose and HbA1C between vitamin D and control groups. Results: A total of 10 randomized controlled trials were included. Vitamin D did not significantly improve 2–h oral glucose tolerance test plasma glucose: the mean differences were – 0.06 (95% CI –0.36 to 0.24) and –0.23 mmol/l (95% CI –0.65 to 0.19), respectively. Conclusions: Low beneficial effect of Vitamin D improving the blood glucose levels in prediabetes was identified.