Effect of Carbondioxide Pneumoperitoneum on Liver Function in Laparoscopic Cholecystectomy At Vims, Bellary

Dr Praveen Khandelwal; Dr Pradeep Y M; Dr Vidyadhar A Kinhal; Dr Ramesh K

Volume : III, Issue : IX, September - 2014

Effect of Carbondioxide Pneumoperitoneum on Liver Function in Laparoscopic Cholecystectomy At Vims, Bellary

Dr Praveen Khandelwal, Dr Pradeep Y M, Dr Vidyadhar A Kinhal, Dr Ramesh K

Abstract :

Introduction: The laparoscopic cholecystectomy offers many advantages that include a markedly reduction in hospital stay and decreased cost. Because of these distinct advantages, the procedure has gained worldwide popularity and has now become one of the most common operations performed in general surgical practice. Aim of the study: The purpose of this study was to investigate the effect of laparoscopic cholecystectomy on liver function in humans and the possible mechanisms behind such effect. Methods: Blood samples were collected from 50 patients undergoing laparoscopic cholecystectomy preoperatively once and post operatively on day 1. They were tested for liver function by comp� the level of serum bilirubin(total and direct), serum alanine amino transferase (ALT), serum aspartate aminotransferase (AST) , serum alkaline phosphatase and serum gamma glutamyl transferase. Post operative oral feeds and length of hospital stay was also measured. Results : The level of serum AST, ALT, bilirubin ( total and direct ),ALP and GGT increased significantly during the first 24 hrs. post operatively after laparoscopic cholecystectomy as compared to baseline values. Conclusion: Transient elevation of hepatic enzymes occurs after laparoscopic cholecystectomy and the major causative factor seemed to be CO2 pneumoperitoneum.